Across TCGA cell cohorts, SETD4 mutation is significantly associated with the mutation status of many other genes, with 2,405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETD4-associated genes across cancer lineages are NOTCH2, COL7A1, and IPO5. Each is linked with SETD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SETD4-to-partner and partner-to-SETD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD4→partner) and Y-score (partner→SETD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOTCH2 →	+2.043	+3.693	.009	.009	1	4
BLOOD_Leukemia	COL7A1 →	+2.560	+4.364	.002	.002	1	4
BREAST	IPO5 →	+5.297	+5.297	.004	.004	1	3
BLOOD_Lymphoma	DLGAP2 →	+2.710	+4.203	.008	.008	1	3
BLOOD_Lymphoma	SCAF8 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Leukemia	CUX1 →	+3.560	+5.209	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,405 associations by consensus.

Exploration

SETD4 survival (RNA) · tumor vs normal (RNA) · all SETD4 data types