SETD4-AS1

Across TCGA pan-cancer cohorts, SETD4-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SETD4-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SETD4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETD4-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and UCS show a favorable association.

COAD, ACC, and OV are the cancer types where SETD4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.716	0.887	.004	51	view →
ACC	DFS	Tertile	All	0.117	0.575	<.001	51	view →
OV	OS	Median	All	0.889	0.794	.002	40	view →
UCS	OS	Tertile	All	0.723	0.480	.032	18	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
SARC	OS	Quartile	All	0.964	0.778	.003	18	view →
LUAD	DFS	Quartile	All	0.864	0.727	.010	13	view →
MESO	OS	Quartile	III,IV	0.396	0.609	.023	12	view →
UVM	DFS	Tertile	III,IV	0.172	0.821	.002	12	view →
STAD	DFS	Quartile	III,IV	0.648	0.380	.030	7	view →
LUSC	DFS	Tertile	II,III,IV	0.548	0.336	.037	6	view →
SKCM	DFS	Quartile	IV	0.040	0.591	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SETD4-AS1–COAD (OS)

Open the COAD breakdown →