SETD4-AS1

Across TCGA pan-cancer cohorts, SETD4-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SETD4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SETD4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SETD4-AS1 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

LUSC, PRAD, and LUAD are the cancer types where SETD4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETD4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.116	.026	2	view →
PRAD	All	All	+0.093	.017	2	view →
LUAD	Male	II,III,IV	+0.090	.034	2	view →
BRCA	All	III,IV	−0.073	.007	2	view →
KIRC	All	All	−0.045	.014	2	view →
KICH	Female	All	+0.198	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SETD4-AS1–LUSC

Open the LUSC breakdown →