SETD3

Across TCGA cell cohorts, SETD3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETD3-associated genes across cancer lineages are LGI1, CBLN4, and BRDT. Each is linked with SETD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD3-to-partner and partner-to-SETD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by SETD3-low versus SETD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD3→partner) and Y-score (partner→SETD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	BRDT →	+0.111	+3.333	<.001	.009	3	1
LARGE_INTESTINE	CFAP47 →	+0.194	+3.716	.005	.003	3	1
LARGE_INTESTINE	YIPF7 →	+0.062	+2.878	.002	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.537	+3.748	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

LGI1 by SETD3 expression — BLOOD_Leukemia

Explore this box plot interactively →