SETD1A

Across TCGA pan-cancer cohorts, SETD1A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SETD1A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SETD1A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SETD1A is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where SETD1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETD1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.294	<.001	11	view →
LSCC	Female	All	+0.159	<.001	7	view →
PDAC	Male	All	−0.240	.004	3	view →
HNSC	All	II,III,IV	+0.058	.030	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SETD1A–CCRCC

Open the CCRCC breakdown →