SETD1A

Across TCGA pan-cancer cohorts, SETD1A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SETD1A data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SETD1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated SETD1A expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

ESCA, HNSC, and LIHC are the cancer types where SETD1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	II,III,IV	0.724	0.365	.002	31	view →
HNSC	DFS	Tertile	IV	0.763	0.532	<.001	31	view →
LIHC	DFS	Tertile	All	0.440	0.592	.004	24	view →
UVM	DFS	Tertile	III,IV	0.855	0.271	.005	19	view →
THYM	DFS	Median	III,IV	1.000	0.386	.002	18	view →
BLCA	DFS	Quartile	All	0.294	0.633	.007	16	view →
COAD	DFS	Quartile	All	0.757	0.843	.016	16	view →
READ	OS	Median	II,III,IV	0.846	0.316	.008	16	view →
GBM	DFS	Tertile	All	0.403	0.210	.012	12	view →
MESO	DFS	Tertile	IV	0.383	0.875	.006	12	view →
CHOL	DFS	Quartile	All	1.000	0.082	.041	12	view →
UCS	OS	Median	IV	0.732	0.224	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SETD1A–ESCA (OS)

Open the ESCA breakdown →