SETD1A

Across TCGA patient cohorts, SETD1A mutation is significantly associated with the RNA expression of many other genes, with 4,272 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD1A-associated genes across cancer lineages are NUSAP1, AUNIP, and CDCA5. Each is linked with SETD1A in more than 4 cancer types. Because this analysis shows association rather than direction, both SETD1A-to-partner and partner-to-SETD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUSAP1 grouped by SETD1A-low versus SETD1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1A→partner) and Y-score (partner→SETD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUSAP1 →	+0.742	+2.000	<.001	<.001	3	5
COAD	AUNIP →	+0.575	+2.861	<.001	.001	3	5
UCEC	CDCA5 →	+0.606	+2.070	.001	.001	3	5
UCEC	RAD51 →	+0.723	+2.010	<.001	<.001	3	5
STAD	MRPS30 →	+0.460	+3.700	.003	.001	3	4
UCEC	ZWINT →	+0.755	+2.000	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,272 associations by consensus.

NUSAP1 by SETD1A expression — UCEC

Explore this box plot interactively →