SETD1A

Across TCGA patient cohorts, SETD1A mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD1A-associated genes across cancer lineages are PCNA, ASNS, and Cyclin-B1. Each is linked with SETD1A in more than 3 cancer types. Because this analysis shows association rather than direction, both SETD1A-to-partner and partner-to-SETD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SETD1A-low versus SETD1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1A→partner) and Y-score (partner→SETD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.233	+2.502	<.001	.001	3	4
STAD	ASNS →	+0.485	+3.000	.019	.034	3	3
UCEC	Cyclin-B1 →	+0.629	+3.906	<.001	<.001	3	3
SKCM	MSH6 →	-0.279	-2.115	.047	.018	3	3
COAD	Rad50 →	-0.344	-3.296	<.001	.009	3	3
COAD	ATM →	-0.658	-2.321	<.001	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PCNA by SETD1A expression — UCEC

Explore this box plot interactively →