SETD1A

Across TCGA cell cohorts, SETD1A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,537 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SETD1A-associated GO terms across cancer lineages are CAMP/PKA signal transduction, Establishment of RNA localization, and Regulation of DNA repair. Each is linked with SETD1A in more than 18 cancer types. Because this analysis shows association rather than direction, both SETD1A-to-partner and partner-to-SETD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAMP/PKA signal transduction grouped by SETD1A-low versus SETD1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1A→partner) and Y-score (partner→SETD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAMP/PKA signal transduction →	+0.210	+0.794	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.132	+1.150	<.001	<.001	3	18
SOFT_TISSUE	Regulation of DNA repair →	+0.074	+1.001	<.001	<.001	3	18
OESOPHAGUS	RNA export from nucleus →	+0.129	+0.725	<.001	<.001	3	18
LUNG_SCLC	Regulation of chromatin organization →	+0.130	+0.639	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.093	+1.105	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,537 associations by consensus.

CAMP/PKA signal transduction by SETD1A expression — BONE

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