SETD1A

Across TCGA cell cohorts, SETD1A mutation is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETD1A-associated genes across cancer lineages are MUC5AC, OR11H12, and OR1K1. Each is linked with SETD1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD1A-to-partner and partner-to-SETD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC5AC grouped by SETD1A-low versus SETD1A-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1A→partner) and Y-score (partner→SETD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MUC5AC →	+0.018	+4.807	<.001	.006	3	2
SOFT_TISSUE	OR11H12 →	+0.039	+3.637	<.001	.002	3	2
LUNG_SCLC	OR1K1 →	+0.030	+3.898	.003	.005	3	2
LUNG_SCLC	OR4C6 →	+0.016	+4.169	.006	.001	3	2
LUNG_SCLC	TEX43 →	+0.194	+3.523	<.001	.008	3	2
SOFT_TISSUE	TSSK2 →	+0.351	+3.876	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

MUC5AC by SETD1A expression — BLOOD_Myeloma

Explore this box plot interactively →