SETBP1

Across TCGA pan-cancer cohorts, SETBP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SETBP1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SETBP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SETBP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

ESCA, SKCM, and PCPG are the cancer types where SETBP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	24	view →
SKCM	DFS	Median	II,III,IV	0.818	0.657	.023	7	view →
PCPG	DFS	Median	All	0.088	0.768	.002	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	OS	Median	All	0.149	0.686	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SETBP1–ESCA (OS)

Open the ESCA breakdown →