SETBP1

Across TCGA pan-cancer cohorts, SETBP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SETBP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SETBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types SETBP1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where SETBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SETBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.388	<.001	12	view →
KIRC	All	II,III,IV	−0.900	<.001	11	view →
THCA	Male	III,IV	−1.545	<.001	10	view →
UCEC	All	All	−2.071	<.001	8	view →
KICH	All	All	−1.047	<.001	8	view →
HNSC	Female	III,IV	+1.153	.006	7	view →
KIRP	Male	All	−0.952	<.001	7	view →
LUAD	All	All	−0.533	<.001	7	view →
BLCA	All	All	−0.928	.013	6	view →
BRCA	Female	II,III,IV	−0.659	<.001	6	view →
STAD	All	All	−0.971	.003	4	view →
READ	All	All	−1.722	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SETBP1–COAD

Open the COAD breakdown →