SETBP1

Across TCGA patient cohorts, SETBP1 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SETBP1-associated genes across cancer lineages are Cyclin-B1, p27_pT157, and 4E-BP1. Each is linked with SETBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SETBP1-to-partner and partner-to-SETBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SETBP1-low versus SETBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETBP1→partner) and Y-score (partner→SETBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.480	+1.874	.001	.001	3	4
COAD	p27_pT157 →	+0.218	+2.095	<.001	.003	3	3
BLCA	4E-BP1 →	+0.355	+2.824	.016	.036	2	4
STAD	ER-alpha_pS118 →	+0.073	+2.222	.024	.010	3	3
STAD	Cyclin-E2 →	+0.170	+2.190	<.001	.030	3	3
UCEC	Annexin-1 →	+0.396	+1.460	.004	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Cyclin-B1 by SETBP1 expression — UCEC

Explore this box plot interactively →