SETBP1

Across TCGA cell cohorts, SETBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,251 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SETBP1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Regulation of cell cycle G1/S phase transition, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with SETBP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SETBP1-to-partner and partner-to-SETBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SETBP1-low versus SETBP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETBP1→partner) and Y-score (partner→SETBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.106	+2.243	<.001	<.001	3	13
STOMACH	Regulation of cell cycle G1/S phase transition →	+0.070	+1.319	<.001	.002	3	12
LUNG_SCLC	Regulation of G1/S transition of mitotic cell cycle →	+0.094	+2.498	<.001	<.001	3	12
STOMACH	Negative regulation of myoblast fusion →	+0.115	+1.155	.002	.005	1	13
LUNG_SCLC	Regulation of stem cell population maintenance →	+0.089	+1.850	<.001	<.001	3	11
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.071	+1.763	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,251 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SETBP1 expression — LUNG_SCLC

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