SETBP1

Across TCGA cell cohorts, SETBP1 mutation is significantly associated with the RNA expression of many other genes, with 448 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETBP1-associated genes across cancer lineages are TEX43, CRACD, and PCGF1. Each is linked with SETBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SETBP1-to-partner and partner-to-SETBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by SETBP1-low versus SETBP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETBP1→partner) and Y-score (partner→SETBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX43 →	+0.112	+2.616	<.001	.005	3	2
LUNG_NSCLC_LUAD	CRACD →	+0.974	+2.736	<.001	.001	3	2
LUNG_NSCLC_LUAD	PCGF1 →	+0.568	+3.321	<.001	.003	3	2
LARGE_INTESTINE	KLRG1 →	+0.558	+3.169	.003	.006	3	2
LARGE_INTESTINE	RAVER2 →	+0.746	+3.169	.003	.009	3	2
LUNG_NSCLC_LUAD	ING5 →	+0.533	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 448 associations by consensus.

TEX43 by SETBP1 expression — LUNG_SCLC

Explore this box plot interactively →