SET

Across TCGA patient cohorts, SET mutation is significantly associated with the RNA expression of many other genes, with 1,938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SET-associated genes across cancer lineages are RN7SL478P, MIR6803, and LINC02438. Each is linked with SET in more than 1 cancer types. Because this analysis shows association rather than direction, both SET-to-partner and partner-to-SET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by SET-low versus SET-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SET→partner) and Y-score (partner→SET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL478P →	+0.244	+3.269	<.001	.008	3	2
UCEC	MIR6803 →	+0.109	+3.954	<.001	.006	3	2
UCEC	LINC02438 →	+0.760	+2.392	<.001	<.001	3	2
SKCM	RNU6-624P →	+0.283	+7.816	<.001	.008	3	1
CESC	LINC02596 →	+0.166	+4.119	<.001	.002	3	1
CESC	HMGB3P12 →	+0.037	+4.144	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,938 associations by consensus.

RN7SL478P by SET expression — CESC

Explore this box plot interactively →