SESN3

Across TCGA cell cohorts, SESN3 mutation is significantly associated with the mutation status of many other genes, with 2,683 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SESN3-associated genes across cancer lineages are PCDHB3, NLRP3, and GFRAL. Each is linked with SESN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SESN3-to-partner and partner-to-SESN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHB3 grouped by SESN3-low versus SESN3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN3→partner) and Y-score (partner→SESN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCDHB3 →	+3.722	+4.022	.003	.003	1	3
BLOOD_Leukemia	NLRP3 →	+4.894	+5.870	<.001	<.001	1	3
BLOOD_Leukemia	GFRAL →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	ZNF418 →	+4.157	+5.430	<.001	<.001	1	3
LARGE_INTESTINE	ABCB5 →	+2.159	+3.807	.007	.007	1	3
BLOOD_Leukemia	SOX5 →	+3.894	+5.247	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,683 associations by consensus.

PCDHB3 by SESN3 expression — LUNG_SCLC

Explore this box plot interactively →