SESN1

Across TCGA patient cohorts, SESN1 mutation is significantly associated with the RNA expression of many other genes, with 1,339 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SESN1-associated genes across cancer lineages are H2AB3, RNA5SP282, and FABP12P1. Each is linked with SESN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SESN1-to-partner and partner-to-SESN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AB3 grouped by SESN1-low versus SESN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN1→partner) and Y-score (partner→SESN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AB3 →	+0.018	+4.478	<.001	.003	3	2
BLCA	RNA5SP282 →	+0.358	+2.588	<.001	.009	3	2
HNSC	FABP12P1 →	+0.382	+6.763	<.001	<.001	3	2
SKCM	RNU6-660P →	+0.538	+4.469	<.001	.006	3	2
BLCA	LINC02706 →	+0.052	+4.825	<.001	.002	3	2
HNSC	HAUS1P3 →	+0.111	+5.655	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,339 associations by consensus.

H2AB3 by SESN1 expression — UCEC

Explore this box plot interactively →