SESN1

Across TCGA pan-cancer cohorts, SESN1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SESN1 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SESN1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SESN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and CESC are the cancer types where SESN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.795	0.706	<.001	124	view →
KIRC	OS	Median	All	0.710	0.564	<.001	116	view →
CESC	DFS	Tertile	III,IV	0.296	0.747	.008	38	view →
LUAD	DFS	Quartile	All	0.839	0.701	.002	31	view →
PAAD	DFS	Median	All	0.450	0.274	<.001	30	view →
SCLC	OS	Median	All	0.535	0.747	.005	29	view →
UCS	OS	Median	All	0.558	0.793	.012	28	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LAML	DFS	Quartile	All	0.220	0.699	.001	24	view →
MESO	DFS	Median	IV	0.206	0.505	.012	18	view →
THCA	OS	Tertile	III,IV	0.982	0.879	.025	18	view →
PRAD	OS	Median	All	1.000	0.977	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SESN1–HNSC (OS)

Open the HNSC breakdown →