SESN1

Across TCGA patient cohorts, SESN1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SESN1-associated genes across cancer lineages are HER3_pY1289, p27_pT198, and p62 Lck ligand. Each is linked with SESN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SESN1-to-partner and partner-to-SESN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by SESN1-low versus SESN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN1→partner) and Y-score (partner→SESN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.084	+2.189	.031	.034	3	1
UCEC	p27_pT198 →	+0.123	+2.700	.010	.006	3	1
UCEC	p62 Lck ligand →	+0.380	+3.469	.009	.002	3	1
UCEC	STAT5a →	+0.484	+2.000	.007	.032	3	1
UCEC	Caspase-8 →	-0.268	-3.459	.018	.005	3	1
UCEC	C-Raf →	+0.197	+2.321	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

HER3_pY1289 by SESN1 expression — UCEC

Explore this box plot interactively →