SESN1

Across TCGA cell cohorts, SESN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,153 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SESN1-associated GO terms across cancer lineages are Response to L-leucine, Cellular response to L-leucine, and Response to amino acid starvation. Each is linked with SESN1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SESN1-to-partner and partner-to-SESN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to L-leucine grouped by SESN1-low versus SESN1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN1→partner) and Y-score (partner→SESN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to L-leucine →	+0.096	+1.692	<.001	<.001	3	14
SKIN	Cellular response to L-leucine →	+0.095	+1.138	<.001	<.001	3	14
SKIN	Response to amino acid starvation →	+0.058	+0.919	.001	<.001	3	11
CNS	Response to vitamin B1 →	+0.146	+0.884	<.001	<.001	3	10
SKIN	Cellular response to amino acid starvation →	+0.074	+0.938	<.001	.001	3	10
SOFT_TISSUE	Regulation of response to reactive oxygen species →	+0.147	+0.820	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,153 associations by consensus.

Response to L-leucine by SESN1 expression — STOMACH

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