SERTAD4

Across TCGA patient cohorts, SERTAD4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERTAD4-associated genes across cancer lineages are MEK1, EGFR_pY1068, and PCNA. Each is linked with SERTAD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERTAD4-to-partner and partner-to-SERTAD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SERTAD4-low versus SERTAD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTAD4→partner) and Y-score (partner→SERTAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.380	+2.087	.006	.005	3	3
UCEC	EGFR_pY1068 →	-0.255	-3.247	.008	<.001	3	2
UCEC	PCNA →	+0.253	+3.247	.002	<.001	3	2
UCEC	PDCD4 →	-0.604	-2.105	<.001	.017	3	2
UCEC	Src_pY527 →	-0.347	-2.311	.035	.034	3	2
UCEC	A-Raf_pS299 →	-0.110	-2.584	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by SERTAD4 expression — UCEC

Explore this box plot interactively →