SERTAD4

Across TCGA pan-cancer cohorts, SERTAD4 RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated SERTAD4 data layer compared with 8 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SERTAD4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERTAD4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

UVM, KIRC, and THYM are the cancer types where SERTAD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.304	0.712	<.001	87	view →
KIRC	DFS	Median	II,III,IV	0.774	0.531	<.001	82	view →
THYM	DFS	Quartile	II,III,IV	0.906	0.428	<.001	26	view →
UCS	OS	Tertile	II,III,IV	0.562	0.207	.014	26	view →
OV	OS	Median	III,IV	0.736	0.632	.008	18	view →
PAAD	OS	Median	All	0.397	0.581	.021	14	view →
LAML	DFS	Tertile	All	0.483	0.279	.012	14	view →
BRCA	OS	Quartile	II,III,IV	0.882	0.941	.010	13	view →
ESCA	OS	Quartile	All	0.825	0.601	.007	12	view →
ACC	DFS	Tertile	All	0.657	0.340	.022	12	view →
COAD	OS	Tertile	All	0.877	0.702	.012	11	view →
SARC	DFS	Tertile	All	0.753	0.537	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

SERTAD4–UVM (DFS)

Open the UVM breakdown →