SERPINI1

Across TCGA patient cohorts, SERPINI1 mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINI1-associated genes across cancer lineages are RNA5SP143, RNA5SP321, and RNA5SP329. Each is linked with SERPINI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINI1-to-partner and partner-to-SERPINI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP143 grouped by SERPINI1-low versus SERPINI1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINI1→partner) and Y-score (partner→SERPINI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP143 →	+0.255	+7.731	<.001	.009	3	2
CESC	RNA5SP321 →	+0.383	+5.539	<.001	.004	3	2
LUAD	RNA5SP329 →	+0.409	+4.502	<.001	.007	3	2
LUAD	RNU6-18P →	+0.442	+5.139	<.001	<.001	3	2
LUAD	TRIM64EP →	+0.112	+5.523	<.001	.001	3	2
UCEC	MRPS15 →	+0.405	+3.212	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

RNA5SP143 by SERPINI1 expression — BRCA

Explore this box plot interactively →