SERPING1

Across TCGA pan-cancer cohorts, SERPING1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SERPING1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SERPING1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPING1 expression acts as an unfavorable survival marker, although some lineages such as GBM and OV show a favorable association.

UCEC, LUAD, and COAD are the cancer types where SERPING1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.233	1.000	<.001	54	view →
LUAD	OS	Median	III,IV	0.223	0.691	.005	34	view →
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	12	view →
GBM	DFS	Median	All	0.492	0.259	.009	9	view →
LSCC	DFS	Tertile	II,III,IV	0.825	1.000	.016	8	view →
OV	DFS	Median	All	1.000	0.855	.027	4	view →
CCRCC	DFS	Median	All	0.861	0.653	.025	4	view →
HNSC	OS	Tertile	All	0.953	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SERPING1–UCEC (DFS)

Open the UCEC breakdown →