SERPING1

Across TCGA pan-cancer cohorts, SERPING1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SERPING1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SERPING1 RNA is repressed in tumor relative to normal tissue. In most cancer types SERPING1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and BLCA are the cancer types where SERPING1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPING1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.530	<.001	11	view →
LUAD	Male	All	−1.529	<.001	9	view →
BLCA	Male	III,IV	−2.144	<.001	8	view →
LUSC	Male	All	−1.750	<.001	8	view →
KIRC	Male	All	+1.035	<.001	7	view →
LIHC	Female	All	−0.916	<.001	7	view →
UCEC	All	III,IV	−2.368	<.001	6	view →
BRCA	All	II,III,IV	−1.203	<.001	6	view →
HNSC	All	II,III,IV	+0.746	.014	5	view →
CHOL	All	All	−1.586	.011	2	view →
PRAD	All	All	−0.633	<.001	2	view →
READ	Female	All	−1.434	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SERPING1–KICH

Open the KICH breakdown →