SERPING1

Across TCGA patient cohorts, SERPING1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPING1-associated genes across cancer lineages are Fibronectin, IRS1, and JNK2. Each is linked with SERPING1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPING1-to-partner and partner-to-SERPING1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by SERPING1-low versus SERPING1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPING1→partner) and Y-score (partner→SERPING1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.303	-2.000	.041	.032	3	1
UCEC	IRS1 →	+0.216	+2.000	.021	.032	3	1
UCEC	JNK2 →	+0.233	+2.000	.009	.032	3	1
UCEC	Rab11 →	-0.145	-2.700	.026	.006	3	1
UCEC	Rab25 →	-0.495	-3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.261	-3.143	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Fibronectin by SERPING1 expression — UCEC

Explore this box plot interactively →