SERPINF1

Across TCGA patient cohorts, SERPINF1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINF1-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and ACVRL1. Each is linked with SERPINF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINF1-to-partner and partner-to-SERPINF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SERPINF1-low versus SERPINF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINF1→partner) and Y-score (partner→SERPINF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.176	-3.169	.001	.019	2	2
UCEC	FoxM1 →	+0.376	+3.009	.001	.019	3	1
UCEC	ACVRL1 →	-0.155	-2.980	.014	.036	3	1
UCEC	MEK1 →	+0.394	+3.321	.020	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.218	+3.713	.023	<.001	3	1
UCEC	Myosin-IIa →	+0.185	+1.881	.031	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

A-Raf_pS299 by SERPINF1 expression — UCEC

Explore this box plot interactively →