SERPINF1

Across TCGA pan-cancer cohorts, SERPINF1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SERPINF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SERPINF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SERPINF1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

KIRC, BLCA, and THCA are the cancer types where SERPINF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.030	<.001	9	view →
BLCA	Male	All	−2.453	<.001	8	view →
THCA	Female	II,III,IV	−1.767	<.001	8	view →
UCEC	All	All	−2.628	<.001	6	view →
BRCA	All	III,IV	−1.062	<.001	6	view →
CHOL	Male	All	−3.643	<.001	5	view →
KICH	All	All	−1.629	<.001	5	view →
LUAD	Male	III,IV	+1.061	.003	5	view →
LUSC	Female	II,III,IV	+1.407	.005	3	view →
KIRP	Female	II,III,IV	−1.661	.019	2	view →
PRAD	All	All	−0.995	<.001	2	view →
LIHC	Male	All	+0.338	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SERPINF1–KIRC

Open the KIRC breakdown →