SERPINE3

Across TCGA patient cohorts, SERPINE3 mutation is significantly associated with the RNA expression of many other genes, with 1,384 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINE3-associated genes across cancer lineages are MIR548H3, IGLJ6, and RNU6-383P. Each is linked with SERPINE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINE3-to-partner and partner-to-SERPINE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548H3 grouped by SERPINE3-low versus SERPINE3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE3→partner) and Y-score (partner→SERPINE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR548H3 →	+0.709	+5.452	<.001	<.001	3	2
UCEC	IGLJ6 →	+0.891	+2.005	.004	.003	3	2
UCEC	RNU6-383P →	+0.264	+3.038	<.001	.006	3	2
UCEC	DIP2A-IT1 →	+0.335	+2.082	.001	.004	3	2
UCEC	EZH2P1 →	+0.267	+2.279	.004	<.001	3	2
THCA	RNU6-290P →	+0.208	+7.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,384 associations by consensus.

MIR548H3 by SERPINE3 expression — SKCM

Explore this box plot interactively →