SERPINE3

Across TCGA pan-cancer cohorts, SERPINE3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SERPINE3 data layer compared with 4 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SERPINE3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINE3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

OV, SCLC, and KICH are the cancer types where SERPINE3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.303	0.425	.003	64	view →
SCLC	OS	Median	All	0.493	0.183	<.001	56	view →
KICH	OS	Median	All	0.678	1.000	.003	47	view →
LIHC	OS	Quartile	III,IV	0.319	0.764	.002	26	view →
PAAD	DFS	Quartile	All	0.477	0.264	.005	23	view →
LGG	DFS	Median	All	0.776	0.887	<.001	18	view →
BLCA	DFS	Quartile	All	0.144	0.582	.004	16	view →
LUSC	OS	Median	III,IV	0.395	0.703	<.001	12	view →
THCA	OS	Median	All	0.982	0.996	.011	11	view →
UVM	DFS	Median	III,IV	0.212	0.670	.015	11	view →
GBM	OS	Quartile	All	0.536	0.230	.010	10	view →
LUAD	DFS	Median	IV	0.350	0.619	.031	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SERPINE3–OV (OS)

Open the OV breakdown →