SERPINE3

Across TCGA cell cohorts, SERPINE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,241 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SERPINE3-associated GO terms across cancer lineages are Regulation of calcium ion export across plasma membrane, Regulation of DNA-templated transcription initiation, and Negative regulation of DNA-templated transcription initiation. Each is linked with SERPINE3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SERPINE3-to-partner and partner-to-SERPINE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of calcium ion export across plasma membrane grouped by SERPINE3-low versus SERPINE3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE3→partner) and Y-score (partner→SERPINE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of calcium ion export across plasma membrane →	+0.065	+0.049	.009	.009	2	8
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.049	+0.098	<.001	.004	3	7
BLOOD_Leukemia	Negative regulation of DNA-templated transcription initiation →	+0.087	+0.081	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.054	+0.140	<.001	.004	3	7
BLOOD_Leukemia	Negative regulation of transcription initiation by RNA polymerase II →	+0.087	+0.081	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.054	+0.140	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,241 associations by consensus.

Regulation of calcium ion export across plasma membrane by SERPINE3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →