SERPINE3

Across TCGA cell cohorts, SERPINE3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINE3-associated genes across cancer lineages are ASCL3, KRTAP10-8, and DUSP29. Each is linked with SERPINE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINE3-to-partner and partner-to-SERPINE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASCL3 grouped by SERPINE3-low versus SERPINE3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE3→partner) and Y-score (partner→SERPINE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASCL3 →	+0.164	+3.989	<.001	.001	3	1
LARGE_INTESTINE	KRTAP10-8 →	+0.036	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	DUSP29 →	+0.028	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF9 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	MT1HL1 →	+0.049	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4D10 →	+0.004	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ASCL3 by SERPINE3 expression — LARGE_INTESTINE

Explore this box plot interactively →