SERPINE1

Across TCGA pan-cancer cohorts, SERPINE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SERPINE1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERPINE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINE1 expression acts as an unfavorable survival marker.

CCRCC, LUAD, and PDAC are the cancer types where SERPINE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.418	0.887	<.001	60	view →
LUAD	OS	Median	II,III,IV	0.420	0.807	<.001	32	view →
PDAC	OS	Quartile	III,IV	0.184	0.739	.006	32	view →
GBM	DFS	Median	All	0.613	0.819	.002	12	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SERPINE1–CCRCC (DFS)

Open the CCRCC breakdown →