SERPIND1

Across TCGA cell cohorts, SERPIND1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SERPIND1-associated genes across cancer lineages are OR1L3, OR4E1, and NEUROD4. Each is linked with SERPIND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPIND1-to-partner and partner-to-SERPIND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by SERPIND1-low versus SERPIND1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPIND1→partner) and Y-score (partner→SERPIND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	2
BREAST	OR4E1 →	+0.150	+5.781	<.001	.001	3	2
URINARY_TRACT	NEUROD4 →	+0.196	+5.087	<.001	.004	3	1
URINARY_TRACT	UNCX →	+0.013	+5.087	<.001	.004	3	1
CNS	KRTAP11-1 →	+0.017	+4.754	<.001	.005	3	1
CNS	ETDC →	+0.725	+4.754	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR1L3 by SERPIND1 expression — BREAST

Explore this box plot interactively →