SERPINC1

Across TCGA patient cohorts, SERPINC1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINC1-associated genes across cancer lineages are Bak, FASN, and FOXO3a. Each is linked with SERPINC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINC1-to-partner and partner-to-SERPINC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by SERPINC1-low versus SERPINC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINC1→partner) and Y-score (partner→SERPINC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.262	+2.999	.025	.035	3	2
UCEC	FASN →	+0.363	+3.000	.048	.036	3	1
UCEC	FOXO3a →	-0.109	-2.571	.021	.011	3	1
UCEC	VHL →	-1.128	-2.321	<.001	.034	3	1
UCEC	Cyclin-B1 →	+0.699	+2.584	.007	.011	3	1
UCEC	EGFR_pY1068 →	-0.352	-3.321	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Bak by SERPINC1 expression — UCEC

Explore this box plot interactively →