SERPINC1

Across TCGA pan-cancer cohorts, SERPINC1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SERPINC1 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SERPINC1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SERPINC1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and SCLC show a favorable association.

LIHC, STAD, and CHOL are the cancer types where SERPINC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.377	0.234	.001	57	view →
STAD	DFS	Quartile	III,IV	0.421	0.670	.002	43	view →
CHOL	DFS	Median	II,III,IV	0.107	0.546	.008	39	view →
LGG	DFS	Median	All	0.658	0.809	<.001	35	view →
SCLC	DFS	Tertile	II,III,IV	0.651	0.296	.006	24	view →
LUSC	OS	Tertile	III,IV	0.520	0.848	.001	22	view →
KIRP	DFS	Quartile	All	0.939	0.524	.011	18	view →
COAD	DFS	Median	IV	0.599	0.384	.018	16	view →
LUAD	OS	Tertile	All	0.853	0.765	.006	11	view →
MESO	OS	Quartile	IV	0.193	0.869	.009	9	view →
ACC	OS	Median	IV	0.344	0.724	.038	8	view →
UVM	OS	Tertile	All	0.952	0.648	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SERPINC1–LIHC (DFS)

Open the LIHC breakdown →