SERPINC1

Across TCGA cell cohorts, SERPINC1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINC1-associated genes across cancer lineages are XAGE5, MPC1L, and MEIKIN. Each is linked with SERPINC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINC1-to-partner and partner-to-SERPINC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by SERPINC1-low versus SERPINC1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINC1→partner) and Y-score (partner→SERPINC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1
URINARY_TRACT	MEIKIN →	+0.476	+5.087	<.001	.004	3	1
URINARY_TRACT	OR8K3 →	+0.033	+5.087	<.001	.004	3	1
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

XAGE5 by SERPINC1 expression — URINARY_TRACT

Explore this box plot interactively →