SERPINB9

Across TCGA patient cohorts, SERPINB9 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB9-associated genes across cancer lineages are Caspase-8, GSK-3_pS9, and ATM. Each is linked with SERPINB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB9-to-partner and partner-to-SERPINB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SERPINB9-low versus SERPINB9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB9→partner) and Y-score (partner→SERPINB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.303	-2.295	.003	.005	3	2
UCEC	GSK-3_pS9 →	-0.427	-2.000	.010	.030	3	2
UCEC	ATM →	-0.744	-3.446	<.001	.005	3	2
UCEC	eEF2 →	+0.304	+1.807	.039	.027	3	1
UCEC	EGFR_pY1068 →	-0.338	-4.087	.001	<.001	3	1
UCEC	EGFR_pY1173 →	+0.089	+1.833	.007	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-8 by SERPINB9 expression — UCEC

Explore this box plot interactively →