SERPINB9

Across TCGA pan-cancer cohorts, SERPINB9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SERPINB9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SERPINB9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SERPINB9 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and STAD are the cancer types where SERPINB9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINB9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.560	<.001	11	view →
COAD	All	II,III,IV	+0.622	<.001	9	view →
STAD	All	II,III,IV	+1.381	<.001	7	view →
KICH	All	II,III,IV	−1.200	<.001	7	view →
THCA	Female	All	−0.683	<.001	4	view →
ESCA	All	All	+2.030	.001	2	view →
UCEC	All	All	−0.557	.049	2	view →
LUSC	All	All	−0.536	.004	2	view →
BRCA	All	III,IV	−0.389	.036	2	view →
PRAD	All	All	−0.343	.044	2	view →
BLCA	Male	III,IV	+1.177	.023	1	view →
LUAD	Female	III,IV	−0.713	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SERPINB9–KIRC

Open the KIRC breakdown →