SERPINB8

Across TCGA patient cohorts, SERPINB8 mutation is significantly associated with the RNA expression of many other genes, with 3,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB8-associated genes across cancer lineages are AQP7P4, MED19, and GFM2. Each is linked with SERPINB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB8-to-partner and partner-to-SERPINB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P4 grouped by SERPINB8-low versus SERPINB8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB8→partner) and Y-score (partner→SERPINB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	AQP7P4 →	+0.087	+4.539	<.001	.008	3	2
UCEC	MED19 →	+0.318	+1.732	.001	.001	3	2
UCEC	GFM2 →	+0.649	+2.750	<.001	<.001	3	2
UCEC	TERF2IP →	+0.355	+2.332	.004	.003	3	2
UCEC	SNTB2 →	+0.463	+2.332	<.001	.003	3	2
UCEC	HARS1 →	+0.243	+1.818	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,582 associations by consensus.

AQP7P4 by SERPINB8 expression — CESC

Explore this box plot interactively →