SERPINB3

Across TCGA patient cohorts, SERPINB3 mutation is significantly associated with the RNA expression of many other genes, with 1,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB3-associated genes across cancer lineages are TRAIP, DOCK8-AS1, and TEPP. Each is linked with SERPINB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINB3-to-partner and partner-to-SERPINB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIP grouped by SERPINB3-low versus SERPINB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB3→partner) and Y-score (partner→SERPINB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	+0.497	+2.906	.001	.001	3	3
UCEC	DOCK8-AS1 →	-0.331	-3.689	.009	.001	3	3
SKCM	TEPP →	-0.118	-1.649	.006	.005	3	3
COAD	TERF1P1 →	+0.033	+3.321	<.001	.008	3	2
LUAD	KLHDC8A →	-0.644	-3.558	.008	.002	3	2
LUAD	DTYMK →	+0.504	+2.906	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,789 associations by consensus.

TRAIP by SERPINB3 expression — UCEC

Explore this box plot interactively →