SERPINB3

Across TCGA cell cohorts, SERPINB3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SERPINB3-associated genes across cancer lineages are SPATA48, ENTHD1, and OR52E8. Each is linked with SERPINB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB3-to-partner and partner-to-SERPINB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by SERPINB3-low versus SERPINB3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB3→partner) and Y-score (partner→SERPINB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA48 →	+0.021	+4.169	<.001	.001	3	1
LUNG_SCLC	ENTHD1 →	+0.159	+3.898	.003	.005	3	1
LUNG_SCLC	OR52E8 →	+0.032	+4.058	<.001	.007	3	1
LUNG_SCLC	SLCO1B7 →	+0.259	+3.898	<.001	.005	3	1
LUNG_SCLC	MFRP →	+0.010	+3.898	<.001	.005	3	1
BLOOD_Lymphoma	FCN2 →	+0.048	+4.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SPATA48 by SERPINB3 expression — LUNG_SCLC

Explore this box plot interactively →