SERPINB12

Across TCGA cell cohorts, SERPINB12 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINB12-associated genes across cancer lineages are DEFA3, CLEC4C, and F9. Each is linked with SERPINB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB12-to-partner and partner-to-SERPINB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by SERPINB12-low versus SERPINB12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB12→partner) and Y-score (partner→SERPINB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA3 →	+0.180	+4.887	<.001	.009	3	1
LUNG_SCLC	CLEC4C →	+0.072	+5.029	<.001	.006	3	1
CNS	F9 →	+0.042	+5.321	<.001	.005	3	1
CNS	CST11 →	+0.117	+4.981	<.001	.008	3	1
LARGE_INTESTINE	GFRA4 →	+0.027	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR14K1 →	+0.102	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

DEFA3 by SERPINB12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →