SERPINB1

Across TCGA cell cohorts, SERPINB1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINB1-associated genes across cancer lineages are C14orf180, OOSP4A, and NEXMIF. Each is linked with SERPINB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB1-to-partner and partner-to-SERPINB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by SERPINB1-low versus SERPINB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB1→partner) and Y-score (partner→SERPINB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C14orf180 →	+0.126	+4.155	<.001	.003	3	1
LARGE_INTESTINE	OOSP4A →	+0.115	+3.793	<.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1
CNS	OR14C36 →	+0.021	+5.754	.007	.002	3	1
BLOOD_Lymphoma	ACOD1 →	+0.006	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TSHB →	+0.068	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C14orf180 by SERPINB1 expression — LARGE_INTESTINE

Explore this box plot interactively →