SERPINA9

Across TCGA cell cohorts, SERPINA9 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SERPINA9-associated genes across cancer lineages are LRRTM3, SLC5A8, and ADAM30. Each is linked with SERPINA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA9-to-partner and partner-to-SERPINA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRTM3 grouped by SERPINA9-low versus SERPINA9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA9→partner) and Y-score (partner→SERPINA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRRTM3 →	+0.075	+3.921	.002	.001	3	2
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
SKIN	ADAM30 →	+0.045	+3.217	.001	.006	3	1
SKIN	SIT1 →	+0.086	+3.426	<.001	.007	3	1
SKIN	POU4F2 →	+0.417	+4.000	<.001	<.001	3	1
SKIN	OR14K1 →	+0.160	+3.447	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

LRRTM3 by SERPINA9 expression — SKIN

Explore this box plot interactively →