Across TCGA patient cohorts, SERPINA3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,976 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SERPINA3-associated genes across cancer lineages are CD93, VGLL3, and STAB1. Each is linked with SERPINA3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SERPINA3-to-partner and partner-to-SERPINA3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA3→partner) and Y-score (partner→SERPINA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD93 →	+0.914	+0.773	<.001	.002	3	8
OV	VGLL3 →	+1.001	+0.805	<.001	<.001	3	8
GBM	STAB1 →	+0.947	+0.586	<.001	<.001	3	7
BRCA	MEIS3 →	+0.799	+0.512	.002	<.001	3	7
BRCA	CNRIP1 →	+0.773	+0.484	<.001	<.001	3	7
BRCA	RECK →	+0.781	+0.503	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,976 associations by consensus.

Exploration

SERPINA3 survival (RNA) · tumor vs normal (RNA) · all SERPINA3 data types