Across TCGA pan-cancer cohorts, SERPINA3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SERPINA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SERPINA3 RNA is repressed in tumor relative to normal tissue. In most cancer types SERPINA3 is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

KIRC, LIHC, and PRAD are the cancer types where SERPINA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.252	.003	5	view →
LIHC	All	All	−0.936	.001	2	view →
PRAD	All	All	+0.688	.001	2	view →
ESCA	All	All	+1.177	.014	1	view →
LUSC	All	II,III,IV	−0.531	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SERPINA3 RNA expression & survival · all SERPINA3 data types