Across TCGA patient cohorts, SERPINA3 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA3-associated genes across cancer lineages are eEF2, eIF4G, and A-Raf_pS299. Each is linked with SERPINA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA3-to-partner and partner-to-SERPINA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA3→partner) and Y-score (partner→SERPINA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.430	+3.584	.001	.002	3	3
UCEC	eIF4G →	+0.307	+2.459	.007	.018	3	2
UCEC	A-Raf_pS299 →	-0.164	-2.807	<.001	.003	3	2
SKCM	GAPDH →	+0.501	+2.807	.009	.002	3	2
UCEC	Bax →	+0.191	+1.502	.030	.030	3	2
SKCM	HER2 →	+0.195	+2.128	.035	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

SERPINA3 survival (RNA) · tumor vs normal (RNA) · all SERPINA3 data types