Across TCGA cell cohorts, SERPINA3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA3-associated genes across cancer lineages are FAM71C, OR1L6, and SPRR1A. Each is linked with SERPINA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA3-to-partner and partner-to-SERPINA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA3→partner) and Y-score (partner→SERPINA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM71C →	+0.018	+3.510	<.001	.003	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CCDC172 →	+0.046	+5.201	.005	.006	3	1
BLOOD_Leukemia	LCE2A →	+0.071	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.050	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SERPINA3 survival (RNA) · tumor vs normal (RNA) · all SERPINA3 data types